Tirzepatide
Dual GIP/GLP-1 receptor agonist · Pre-filled pen
Tirzepatide is a dual agonist that activates both GIP and GLP-1 receptors. Through this combined incretin signalling it enhances glucose-dependent insulin secretion, reduces appetite and slows gastric emptying. These actions support the improvements in glycaemic control and body weight demonstrated in large randomised trials.
Studied use areas
- Type 2 diabetes glycaemic control
- Weight management and body-composition endpoints
- Appetite and satiety regulation
- Metabolic parameters such as HbA1c and lipids
Safety & status
- Prescription-only medicine in the EU and UK (EMA/MHRA); it must be prescribed and supervised by a physician
- Gastrointestinal effects (nausea, diarrhoea, vomiting) are common, particularly during dose escalation
- Requires medical screening (e.g. history of pancreatitis or certain thyroid tumours) and is not for use in pregnancy
- Dose, titration and treatment duration are individualised and set by the treating physician
⚕ Clinical note: This is educational information, not medical advice. Tirzepatide is a prescription-only medicine; any use must be initiated and monitored by a qualified physician, who assesses suitability, benefits and risks individually.
Evidence: Grade A — approved medicine supported by large randomised controlled trials · References: Dual incretin (GIP/GLP-1) receptor agonist randomised controlled trials; EMA/MHRA product information for incretin-based medicines; Peer-reviewed diabetes and obesity-medicine literature




