VIP (Vasoactive Intestinal Peptide)
Neuropeptide immunomodulator (VIP, VPAC receptor agonist) · Pre-filled pen
VIP (vasoactive intestinal peptide) is a naturally occurring neuropeptide that signals through VPAC receptors to relax smooth muscle and to dampen and rebalance inflammatory and immune activity. In immune contexts it is studied for shifting responses toward a more regulated, anti-inflammatory profile. A synthetic form (aviptadil) has been investigated in respiratory and inflammatory conditions, but the evidence remains investigational.
Studied use areas
- Studied for immune modulation and anti-inflammatory signalling balance
- Investigated in respiratory and pulmonary inflammatory conditions as the synthetic form aviptadil
- Explored for vascular smooth-muscle relaxation and circulation-related endpoints
- Examined for neuro-circadian and gastrointestinal-motility signalling roles
Safety & status
- Investigational for immune indications; the synthetic form has been trialled but is not an established immune therapy in the EU/UK
- Its vasodilatory action can produce flushing and blood-pressure changes, as reported in studies
- It is not appropriate for self-directed immune use and requires physician supervision
⚕ Clinical note: This is educational information, not medical advice. VIP is a genuine signalling peptide, but its use for immune purposes is investigational and any benefit remains unproven in that setting. It is not a substitute for established care, and suitability must be assessed and monitored under physician supervision.
Evidence: Grade C — investigational for immune indications; the synthetic form has been trialled but is not an established therapy · References: peer-reviewed neuroimmunology and pulmonary research literature; clinical trial reports on aviptadil (synthetic VIP); reviews of VIP and VPAC receptor pharmacology




