Teriparatide
Recombinant parathyroid hormone (PTH 1-34); anabolic osteoporosis medicine · Pre-filled pen
Teriparatide is a recombinant fragment of parathyroid hormone (PTH 1-34) that, when given intermittently, preferentially stimulates osteoblasts to build new bone, shifting bone remodelling toward formation. This anabolic action improves bone microarchitecture and, in trials, reduces the risk of vertebral and non-vertebral fractures. In a longevity context its role is specifically bone health in people with osteoporosis or high fracture risk.
Studied use areas
- Osteoporosis with high fracture risk (approved indication)
- Bone-formation and bone-density improvement
- Bone microarchitecture and skeletal-strength support
- Glucocorticoid-induced bone loss (approved context)
Safety & status
- Prescription-only medicine in the EU and UK; must be prescribed and monitored by a physician
- Contraindicated in certain conditions (e.g. some bone cancers, unexplained high calcium, prior skeletal radiation); assessment is essential
- Can cause side effects such as dizziness, leg cramps, nausea and raised blood calcium
- Approved for a limited treatment duration under EMA/MHRA labelling
⚕ Clinical note: This is educational information only and not medical advice. Teriparatide is a prescription-only medicine; the decision to use it and any regimen must be individualised and determined by a treating physician.
Evidence: Grade A — approved, prescription-only medicine with randomised controlled trial evidence for reducing fractures in osteoporosis. · References: EMA/MHRA product information for teriparatide; Randomised controlled trials of anabolic osteoporosis therapy; International osteoporosis treatment guidelines




