VIP + MOTS-c (Blend)
Investigational immune/metabolic peptide blend (VIP + MOTS-c) · Pre-filled pen
This blend combines two signalling peptides from different biology. VIP is an endogenous 28-amino-acid neuropeptide studied for immune-modulating and anti-inflammatory effects through VPAC receptor signalling and regulation of T-cell and macrophage activity. MOTS-c is a mitochondrial-derived peptide investigated for metabolic and longevity-related signalling, including AMPK activation and influence on insulin sensitivity and cellular stress responses. The blend is intended to overlay immune-regulatory and metabolic pathways, but the combination has not been characterised in controlled human studies.
Studied use areas
- Investigated for immune regulation and anti-inflammatory signalling (VIP component)
- Studied for insulin-sensitivity and mitochondrial-stress pathways (MOTS-c component)
- Explored in preclinical longevity and exercise-mimetic research (MOTS-c)
- Positioned for physician-directed research combining immune and metabolic pathways
Safety & status
- Investigational blend; robust human trial data are lacking for both components, especially in combination
- Combining compounds compounds the uncertainty — additive or interacting effects on immune and metabolic signalling are poorly characterised, so physician supervision is mandatory
- Not for use in pregnancy or breastfeeding; VIP can cause vasodilation-related effects such as flushing or blood-pressure changes, so clinical oversight is required
⚕ Clinical note: This is educational information, not medical advice. This VIP + MOTS-c blend is investigational, and combining compounds increases the uncertainty; it is intended for physician-directed use only and is not a treatment for any immune, metabolic, or age-related condition.
Evidence: Grade D — investigational; limited human data, mainly preclinical · References: Lee C et al., Cell Metabolism, 2015; Delgado M, Ganea D, Amino Acids, 2013; Reynolds JC et al., Nature Communications, 2021




