Melanotan 2
Synthetic α-MSH analogue (non-selective melanocortin receptor agonist) · Pre-filled pen
Melanotan 2 is a synthetic analogue of α-melanocyte stimulating hormone (α-MSH) that activates melanocortin receptors broadly rather than selectively. Through MC1R it drives melanin production (pigmentation), and through central receptors such as MC4R it can influence arousal- and appetite-related signalling. Its non-selective, wide-ranging receptor activity is also the reason its effects and risks are hard to predict.
Studied use areas
- Melanocortin and melanogenesis (pigmentation) signalling research
- Exploratory study of central arousal and desire pathways
- Discussion of appetite-related melanocortin signalling
Safety & status
- Unlicensed and unapproved — no EMA or MHRA marketing authorisation, and regulators have issued warnings against these products
- Reports link it to new, changing or darkening moles and to melanoma concerns; any change in a pigmented skin lesion needs urgent medical review
- Commonly associated with nausea, flushing, blood-pressure changes and uneven pigmentation; product purity and content are not guaranteed
- Not medical advice; if considered at all it must be under physician supervision, with essential skin and mole monitoring
⚕ Clinical note: This card is educational and is not medical advice or an endorsement. Melanotan 2 is an unlicensed, unapproved substance with real safety concerns; Dripfy does not present it as a treatment, and any consideration of it must involve a qualified physician.
Evidence: Grade D — unlicensed and unapproved; sold outside regulatory authorisation, with recognised safety concerns and no quality assurance. · References: MHRA (UK) and HPRA (Ireland) public safety warnings on unlicensed melanotan products; Peer-reviewed dermatology and toxicology case literature; Melanocortin-system pharmacology reviews
