PT-141 (Bremelanotide)
Centrally acting melanocortin receptor agonist · Pre-filled pen
PT-141 (bremelanotide) is a centrally acting melanocortin receptor agonist. It engages melanocortin receptors — MC4R in particular — within brain circuits that govern sexual motivation and arousal, so its primary action is on desire signalling in the CNS rather than on peripheral blood flow. This central mechanism is what distinguishes it from vasodilator-type approaches to sexual function.
Studied use areas
- Female hypoactive sexual desire disorder (HSDD), the approved indication for bremelanotide
- Central (brain-driven) sexual desire and arousal signalling
- Sexual-wellness research in both women and men, depending on screening
- As an approach distinct from blood-flow-focused erectile therapies
Safety & status
- Prescription-only in the EU/UK; supply and use require a qualified prescriber
- Commonly reported effects include nausea, flushing and headache; transient rises in blood pressure and small heart-rate reductions have been described, so cardiovascular screening matters
- Melanocortin activation can trigger focal darkening of skin or gums (hyperpigmentation) in some users
- Not suitable for self-directed use; suitability and any regimen are decided case by case by the treating physician
⚕ Clinical note: This card is educational and is not medical advice, a diagnosis, or a recommendation to use any product. Bremelanotide is a prescription medicine that must be assessed, prescribed and monitored by a qualified physician; never self-source or self-administer it.
Evidence: Grade B — approved as bremelanotide (Vyleesi) for premenopausal HSDD, with supporting randomised controlled trials; benefit is real but modest and patient-selected. · References: EMA/MHRA/FDA product information for melanocortin receptor agonists; Peer-reviewed randomised controlled trials on bremelanotide for HSDD; Pharmacology reviews of centrally acting sexual-medicine agents




